Abstract Some 3-(N-arylcarboxamido)-N-benzylchlorides, bromides and iodides were synthesized by quaternization of N-arylnicotinamides with benzyl halides. N-Arylnicotinamides were obtained by acylation of aniline, 1- and 2-naphthylamines with chloride of nicotinic acid. The synthesized salts were employed in antimicrobial tests against both Gram- negative, Gram-positive bacteria and fungus using the microdilution method. Antimicrobial tests indicated that all salts have reasonable activity but the salts containing iodine anions are more active than others in the series against majority of tested bacteria and fungi strains: Staphylococcus aureus, Escherichia coli, Shigella flexneri, Proteus vulgaris, Pseudomonas aeruginosa, Bacterium antracoides, Bacterium subtilis, S. sonnei, E. aerogenes and Candida albicans.
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