Recent Trends in the Chemistry of Polymers used in Oral Drug Delivery Systems

Tablet is one of the utmost chosen dosage forms administered orally. Disintegrants are substances added to tablets and some encapsulated preparations to encourage the breaking up of both tablet and capsule “slugs” into smaller fragments in an aquatic environment. This increases the surface area that is available and speeds up the release of the drug component. They increase moisture penetration and distribution of the tablet matrix. Tablet disintegration has attracted a lot of attention as an important stage in achieving rapid drug release. The concentration on drug availability emphasizes the significance of a tablet’s comparatively quick disintegration as a criterion for determining unrestricted drug-dissolving behavior. Several factors affect the disintegration replacement of tablets. The primary purpose of the disintegrants is to counteract the effectiveness of the tablet binder and the physical forces that work during compression to prepare the tablet. For the tablet to release its medication, the disintegrating agents must be more effective, and the binder must be stronger. It should ideally cause the tablet to shatter into the powder particles used for the granulation as well as the granules from which it was compressed. This review comprehensively focuses on rationalizing the recent trends in the utilization of natural or synthetic polymers, in designing oral drug delivery systems.
Key words: Tablet, Quality by Design, Polymers, Natural, Synthetic, Immediate release, Extended release, Modified release
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