Microwave Assisted Synthesis, Spectroscopic Characterization and Antimicrobial Activities of Co(II) Complexes Containing Biologically Active Thiosemicarbazone Derivatives
Kamal Kishor Verma and Suresh Kumar Verma
Abstract In present study two thiosemicarbazone ligands i.e. 4HAT and 3NBT and their novel Cobal(II) aryl thiosemicarbazones complexes having the general composition [Co(L1)2Cl2], [Co(L2)2Cl2],{where L1= 4-Hydroxyacetophenone thiosemicarbazones (4HAT), L2 = 3-Nitrobenzaldehyde thiosemicarbazones (3NBT), have been synthesized by the reaction of thiosemicarbazide with substituted aromatic aldehydes and ketones by conventional heating as well as microwave irradiations method followed by complexation with Cobalt(II) metal. The synthesized compounds have been characterised by elemental analysis, melting point determination, FTIR, UV-visible spectral analysis. The synthesized ligands and their new metal complexes have been screened in vitro for antibacterial activity against Escherichia coli, Staphylococcus aureus and Bascillus subtilis bacteria.
Keywords Thiosemicarbazones, Microwave irradiation, Cobalt(II) complexes
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