Abstract Fresh powdered leaves (200 g) of Bombax buonopozense was percolated with 95 % ethanol (1000 cm3) for one week. It was decanted, filtered and evaporated on rota vapor (R110) at 40oC to obtained the crude ethanol extract (F1). It was macerated sequentially with chloroform, ethyl acetate, acetone and water to obtained the chloroform soluble fraction (F2), ethyl acetate soluble fraction (F3), acetone soluble fraction (F4) and water soluble fraction (F5) respectively. All the five fractions were subjected to phytochemical screening to check the presence of some secondary metabolites, also antibacterial screening was carried out against some clinical isolates. Presence of alkaloids, flavonoids, phenolic glycoside, tannins, saponins and anthraquinones were detected in all/ some of the tested fractions. Also a remarkable zones of inhibition on some of the baterial isolates by some fractions were recorded.