Analysis of Postprandial Hyper-triglyceridemia in Type 2 Diabetes Mellitus (T2DM) Patients with Presence of Micro-albuminuria

Abstract It is postulated that in patients with Type 2 Diabetes Mellitus (T2DM) and presence of microalbuminuria (MA) shows higher postprandial triglyceride than those without MA. The present study therefore analyze the potential association and to elaborate the degree of dependence of T2DM with MA condition on onset of high postprandial (PP) triglyceridemia. A total of 49 patients with T2DM were included in the study during January 2012 and December 2015 and were divided into two groups according to the presence (n = 22, MA+ve) or absence of MA (n = 27, MA-ve). Blood was drawn in the fasting state and at 2 and 6 h after the standard mixed breakfast test meal for biochemical parameters. Plasma Biochemical components such as Plasma ApoA, triglycerides, glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, creatinine, Insulin and Glycosylated hemoglobin A1c (HbA1c) levels and urinary components such as Urinary Albumin and micro-albumin were determined using standard methods on Cobas 6000 c501, Hitachi 912, Elecsys 2010 and Cobas e411. Twenty four hr urinary albumin and urinary microalbumin showed highly significant difference (P<0.001) in values in MA-ve and MA+ve groups, whereas glycosylated HbA1c and duration of T2DM doesn’t exhibit any significant difference. Biochemical constituents such as glucose, total cholesterol and HDL-cholesterol exhibited mild (P< 0.05) to moderate (P< 0.01) significance when compared within the groups of MA-ve and MA+ve patients in fasting and postprandial conditions. Comparatively highest level of constantly significant difference in values was noted only in triglycerides when MA+ve was compared with MA-ve, which remains high not only at 2 hrs postprandial (P<0.001) but also after 6 hrs under same conditions (P<0.001). The data strongly support the postulation that T2DM patients with co-existence of MA have significant hypertriglyceridemia, which further complicates already existing co-morbid hyperlipidemic state in these patients.

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Updated: May 8, 2018 — 5:14 am