Chemisty Research Journal

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Synthesis of novel [4, 9-dimethoxy-5H-furo [3, 2-g] chromen-5-one] derivatives with antiproliferative potency towards breast and hepatic cancer cell lines

Abstract Chromen derivative (2) was obtained by the reaction of [cyclohexyl isocyanide, furochromone carbaldehyde (1), cyclohexane-1, 3-dione]. Also, reaction of compound (2) in the presence of semicarbazide hydrochloride to proceed the compound (3) which react with selenium dioxide to form compounds (4). In one-step, the condensation of cyclohexyl isocyanide, furochromone carbaldehyde (1) and pentane-2-dionein pipredine was given compound (5). The mixture of furochromone carbaldehyde (1), barbaturic/or thio-barbaturic acid and cyclohexyl isocyanide was afforded the corresponding compounds (6a,b). While the reaction of furochromonecarbaldehyde (1), Meldrum acid and cyclohexyl isocyanide was yielded the compound (7). The condensation of furochromonecarbaldehyde (1), 1, 3-dicarbonyl compound (cyclohexane-1, 3-dione) with acid derivatives (carboxylic, chlorocarboxylic and cinnamic acid) afforded the corresponding compounds (8a-c). The reaction of furochromonecarbaldehyde (1), dimethyl acetylene dicarboxylate, cyclohexyl isocyanide with 1, 3-dicarbonyle was afforded compound (9). Some of the newly synthesized derivatives showed a reasonable antiproliferative activity towards breast (MCF7) and liver (HEPG2) cancer cell lines in comparison to traditional anticancer agents: 5-Fluorouracil & Doxorubicin.

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