Cyclization of Thiosemicarbazide with substituted aromatic aldehyde over the hazardous reagent and catalyst for the synthesis of 2-amino, 5-aryl-1,3,4-thiadiazoles under microwave irradiation conditions. Screened a sample of a molecule under the conventional and microwave method. The expeditious reaction with good to excellent yield was obtained under the Microwave irradiation method. The synthesized compounds were characterized by IR, 1H NMR and 13C NMR analysis.
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