The in-vitro antimalarial activity of ethanoic and aqueous extracts of Millettia aboensis leaves locally called Atamono was investigated. Organic and aqueous extracts of Millettia Aboensis leaves extracts were tested for their antimalarial activity against Plasmodium falciparum parasite infected whole blood samples with ++ parasite count. The ethanoic and aqueous leaves extracts exhibit high chemosupression of the P. falciparum infected blood samples. The presence of phytochemcials especially alkaloids were responsible for the antimalarial activity of the plant. The result showed that both ethanoic and aqueous leaves extracts of Millettia aboensis demonstrated promising antimalarial activity and there is potential for isolation of lead compounds from their extracts.